Correlation Between Serum Progesterone Level and Menstrual Symptoms in Young Females with Primary Dysmenorrhea

Background: Primary dysmenorrhea (PD) is one of the most common gynecological complaints that affects about 90% of adolescent girls worldwide. Purpose: to ascertain the relationship between menstrual symptoms and serum progesterone levels measured in young females suffering from PD. Methods: One hundred young females between the ages of 17 and 24 with body mass indices between 20 and 25 kg/m² took part in the study. A blood sample of serum progesterone level was taken from all participants on the 21st day of their 28-day menstrual cycles. The Visual Analogue Scale (VAS) was utilized to evaluate the degree of pain, and both the physical and psychological symptoms of PD were assessed by using a menstrual symptom questionnaire (MSQ). Results: There was a significant direct strong correlation between pain and MSQ (r= 0.831) (p=0.001). There was a significant indirect correlation between pain level and serum progesterone (r= -0.199) (p=0.047) and between MSQ and serum progesterone (r= -0.219) (p=0.028). Conclusion: Serum progesterone has a negative correlation with pain intensity and physical and psychological associated symptoms of PD.