Health-enhancing physical activity induce beneficial skeletal muscle mitochondrial adaptations in individuals with rheumatoid arthritis
HEPA can induce beneficial mitochondrial adaptations in skeletal muscle of individuals with RA. However, insufficient compliance and progression in HEPA exercise load led to a reversal of these adaptations. Continuous support and motivation are crucial for maintaining and progressing exercise levels and muscle health in individuals with RA. Key points • Health-enhancing physical activity (HEPA) can induce beneficial mitochondrial adaptations in the skeletal muscle proteome of individuals with RA. • Positive effects on mitochondrial protein levels aligned with the participants compliance to the HEPA intervention. • Results emphasizes that sustaining and progressing exercise regimen is crucial to maintain beneficial adaptations for individuals with RA.
Authors
- Johanna T. Lanner (ORCID: https://orcid.org/0000-0002-1222-9473)
- Jone Vanluyten
- Ingrid E. Lundberg (ORCID: https://orcid.org/0000-0002-6068-9212)
- Birgitta Nordgren (ORCID: https://orcid.org/0000-0001-8903-1273)
- Cecilia Fridén (ORCID: https://orcid.org/0000-0002-6989-719X)
- Emily Shorter (ORCID: https://orcid.org/0000-0001-9431-3742)
- Christina H. Opava (ORCID: https://orcid.org/0000-0001-6738-4879)
- Ferdinand von Walden (ORCID: https://orcid.org/0000-0003-1134-2252)
- Elena Ossipova (ORCID: https://orcid.org/0000-0002-2090-7705)
- Christer Malm (ORCID: https://orcid.org/0000-0002-8436-2476)
- Helena Idborg (ORCID: https://orcid.org/0000-0003-4041-4729)
- Zhengye Liu (ORCID: https://orcid.org/0000-0002-7054-6151)
- Estela Santos‐Alves (ORCID: https://orcid.org/0000-0001-8084-0859)
- Eva Kosek
- Marina Korotkova (ORCID: https://orcid.org/0000-0002-4838-3608)
- P.‐J. Jakobsson
Institutions
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- Karolinska Institutet (SE)
- Mälardalen University (SE)
- Umeå University (SE)
Publication Details
- Journal
- Clinical Rheumatology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1007/s10067-025-07734-z
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00