Low-frequency electroacupuncture attenuates methamphetamine-induced depressive-like behaviors and cognitive impairment via modulating neuroinflammation
The present study suggested that EA alleviates METH-induced depressive-like behaviors and cognitive impairment by modulating neuroinflammation, particularly through the inhibition of microglial activation and pro-inflammatory cytokine release. EA may represent a promising non-pharmacological strategy for the treatment of METH-associated neuropsychiatric disorders.
Authors
- Ludi Zhang (ORCID: https://orcid.org/0000-0003-2061-4563)
- Yueli Zou
- Bing Xie (ORCID: https://orcid.org/0000-0003-2335-5966)
- Xiu‐Jun Yu
- Jiabao Xu (ORCID: https://orcid.org/0000-0001-9197-8052)
- Rongji Hui (ORCID: https://orcid.org/0000-0001-8267-4620)
- Di Wen (ORCID: https://orcid.org/0000-0001-6918-0394)
- Jingyi Zhang (ORCID: https://orcid.org/0000-0002-0931-1302)
- Yi Li (ORCID: https://orcid.org/0000-0002-9415-9930)
- Chunling Ma (ORCID: https://orcid.org/0000-0003-1428-6495)
Institutions
- Hebei Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fneur.2025.1652065
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00