Plasma branched-chain amino acids and risk of radiation-induced acute skin toxicity in women with breast cancer: results from the ATHENA project
The findings highlight that plasma isoleucine is associated with a low risk of ≥ grade 2 AST post-radiotherapy among BC patients. However, further studies such as isoleucine supplementation trials are needed to validate these findings.
Authors
- Savino Cilla (ORCID: https://orcid.org/0000-0001-6711-350X)
- Katia Petroni (ORCID: https://orcid.org/0000-0003-3318-0442)
- Fulvio Mattivi (ORCID: https://orcid.org/0000-0003-4935-5876)
- Sukshma Sharma (ORCID: https://orcid.org/0000-0001-9465-8978)
- Francesco Deodato (ORCID: https://orcid.org/0000-0003-1276-5070)
- Emilia Ruggiero (ORCID: https://orcid.org/0000-0002-7109-1128)
- Augusto Filippo Di Castelnuovo (ORCID: https://orcid.org/0000-0001-9767-7998)
- Chiara Cerletti (ORCID: https://orcid.org/0000-0002-4759-3179)
- Licia Iacoviello (ORCID: https://orcid.org/0000-0003-0514-5885)
- A.G. Morganti (ORCID: https://orcid.org/0000-0001-9793-3410)
- Chiara Tonelli (ORCID: https://orcid.org/0000-0002-9505-3118)
- Andrea Anesi (ORCID: https://orcid.org/0000-0002-9334-2610)
- Maria Benedetta Donati (ORCID: https://orcid.org/0000-0003-1747-5443)
- M. Boccardi (ORCID: https://orcid.org/0000-0001-5071-6099)
- Gabriella Macchia (ORCID: https://orcid.org/0000-0002-0529-201X)
- Francesca Bracone
- Amalia De Curtis (ORCID: https://orcid.org/0000-0001-5104-0318)
- Giovanni de Gaetano
- Marialaura Bonaccio
Institutions
- Fondazione Edmund Mach (IT)
- Università Cattolica del Sacro Cuore (IT)
- University of Milan (IT)
- Istituto Neurologico Mediterraneo (IT)
- Azienda USL di Bologna (IT)
- Consorzio Milano Ricerche (IT)
- LUM Jean Monnet University (IT)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fonc.2025.1653293
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00