Unexpected estradiol decline during ovarian stimulation monitoring affects cumulative live birth
Although E<sub>2</sub> is frequently monitored during COS, the value of routine E<sub>2</sub> monitoring during COS has already been questioned. Our data suggest that the decline in E<sub>2</sub> during COS monitoring is associated with the CLBR following a complete cycle, indicating it remains a critical biomarker in predicting the outcomes during COS. However, the overall size of the association is modest, and further attention should be paid to specific subgroups of patients, such as patients with consecutive E<sub>2</sub> decline.
Authors
- Caihui Ma
- Zhenfang Liu (ORCID: https://orcid.org/0000-0002-6499-6607)
- Jianzhi Ren (ORCID: https://orcid.org/0000-0003-1735-8941)
- Xiaoming Jiang (ORCID: https://orcid.org/0000-0002-8171-6267)
- Jie Geng (ORCID: https://orcid.org/0000-0001-8722-2228)
- Jiali Cai (ORCID: https://orcid.org/0000-0001-8593-8345)
- Xuhong Na
- Kezhen Huang (ORCID: https://orcid.org/0009-0003-1246-7898)
- Haixiao Chen (ORCID: https://orcid.org/0000-0002-4746-7500)
- Lanlan Liu (ORCID: https://orcid.org/0000-0003-0129-9588)
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Xiamen University of Technology (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fendo.2025.1658236
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00