Remimazolam used for sedation during spinal anesthesia puncture provides faster sedation effect and increase recovery rate compared to midazolam: a randomized controlled trial
Remimazolam demonstrated superior recovery in sedation depth, with a significantly shorter time to regain consciousness (RASS -4 to -1), compared with midazolam in patients undergoing ultrasound-guided spinal anesthesia. No significant differences in circulatory or respiratory parameters were observed between groups, though the study may lack power to detect minor safety effects.
Authors
- Zhimin Tan (ORCID: https://orcid.org/0000-0001-6706-8745)
- Jianbo Zhang (ORCID: https://orcid.org/0000-0002-2964-8084)
- Xiaoqiang Li (ORCID: https://orcid.org/0000-0002-9692-1458)
- Peipei Sun (ORCID: https://orcid.org/0000-0001-7130-6830)
- Lianxiong Liang
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Gansu Provincial Hospital (CN)
- Gansu Provincial Maternal and Child Health Hospital (CN)
- Heze Municipal Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fphar.2025.1685312
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00