Detumescence Analgesic Plaster mitigates knee osteoarthritis via active ingredients targeting mitochondrial complex 1/AMPK/MYL3-regulated cartilage homeostasis
This study provides the first evidence that DAP exerts chondroprotective effects by ameliorating mitochondrial dysfunction and oxidative stress in KOA through the mitochondrial complex I/AMPK/MYL3 signaling pathway. These findings offer a mechanistic basis for DAP's clinical efficacy and highlight potential therapeutic targets for KOA management.
Authors
- Yanqiong Zhang (ORCID: https://orcid.org/0000-0002-9358-111X)
- Haiyu Xu (ORCID: https://orcid.org/0000-0001-8994-3053)
- Lü Fu (ORCID: https://orcid.org/0000-0001-9299-3166)
- Ping Wang (ORCID: https://orcid.org/0000-0002-1557-0394)
- Weijie Li (ORCID: https://orcid.org/0000-0002-9238-1335)
- Chunxia Li (ORCID: https://orcid.org/0000-0001-5063-3170)
- Yue Yin (ORCID: https://orcid.org/0000-0002-1640-7337)
- Xiaomei Xiang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1186/s13020-025-01215-w
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences