WNT3A Upregulates the RIP1/HIF-1α/GDF-15 Pathway to Induce EMT and Thereby Increase Colorectal Cancer Cell Migration and Invasion
Our findings demonstrate that the novel WNT3A/RIP1/HIF-1α/GDF-15 signaling axis induces EMT, migration, and invasion in CRC. This pathway might represent a potential therapeutic target for limiting metastatic progression in CRC.
Authors
- Jie Song (ORCID: https://orcid.org/0000-0002-5769-3886)
- Jung‐Yoon Yoo (ORCID: https://orcid.org/0000-0001-9366-3863)
- Jong Kuk Park (ORCID: https://orcid.org/0000-0001-5135-0033)
- Aram Kang (ORCID: https://orcid.org/0000-0002-5274-850X)
- Tae‐Jun Kim (ORCID: https://orcid.org/0000-0003-1991-995X)
- Sang Gu Hwang
Institutions
- Yonsei University (KR)
- Korea Institute of Radiological and Medical Sciences (KR)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-10-20
- DOI
- https://doi.org/10.4143/crt.2025.620
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00