Low b-values in apparent diffusion coefficient calculations overestimate diffusion in rectal cancer
In rectal cancer, tumour ADC calculated using the monoexponential model is strongly influenced by the choice of b-values. By eliminating the contribution from perfusion (b ≤ 100 s/mm2) the uncertainty in the calculations is significantly reduced. Our findings support the use of b-values exceeding 100 s/mm², ideally in combination with a high b-value of at least 1,000 s/mm², when assessing diffusion using the monoexponential model. Consistent b-value combinations across studies are recommended for reliable quantitative comparisons of ADC values.
Authors
- Sara Pilskog (ORCID: https://orcid.org/0000-0002-3475-7939)
- Michael M. Bornstein (ORCID: https://orcid.org/0000-0002-7773-8957)
- Sebastian Meltzer (ORCID: https://orcid.org/0000-0001-6640-3927)
- Stein Harald Holmedal
- Anne Negård (ORCID: https://orcid.org/0000-0002-7624-5595)
- Anne Hansen Ree (ORCID: https://orcid.org/0000-0002-8264-3223)
- Johanna Austrheim Hundvin (ORCID: https://orcid.org/0000-0002-4181-3468)
- Kathrine Røe Redalen (ORCID: https://orcid.org/0000-0002-1172-4632)
Institutions
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Akershus University Hospital (NO)
- Haukeland University Hospital (NO)
- University of Bergen (NO)
Publication Details
- Journal
- Acta Oncologica
- Published
- 2025-10-19
- DOI
- https://doi.org/10.2340/1651-226x.2025.44028
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00