Clinical relevance of next-generation sequencing in patients aged 60 years or younger with pancreatic cancer: A Nationwide prospective cohort study
Complete molecular profiling in PDAC patients ≤ 60 years showed moderate success (55 %) and limited clinical impact, with actionable findings in 13 % and therapy implementation in 3.5 %. Prioritizing KRAS testing and deeper sequencing in KRAS-wildtype tumors, alongside broader access to targeted therapies, may improve outcomes.
Authors
- Gaby J. Strijk (ORCID: https://orcid.org/0009-0008-8916-2300)
- Casper H.J. van Eijck (ORCID: https://orcid.org/0000-0002-9511-2157)
- Floris H. Groenendijk (ORCID: https://orcid.org/0000-0001-5057-561X)
- Nigel G. Kooreman
- Sanne R. Martens‐de Kemp (ORCID: https://orcid.org/0000-0002-8889-1631)
- Judith de Vos‐Geelen (ORCID: https://orcid.org/0000-0003-2578-1766)
- Lodewijk A.A. Brosens (ORCID: https://orcid.org/0000-0003-1341-8994)
- Arantza Fariña Sarasqueta (ORCID: https://orcid.org/0000-0002-4307-1568)
- Geert A. Cirkel (ORCID: https://orcid.org/0009-0007-8712-9825)
- Willem de Koning (ORCID: https://orcid.org/0000-0002-4594-8423)
- Ignace H. J. T. de Hingh (ORCID: https://orcid.org/0000-0003-3491-4268)
- Marjolein Y.V. Homs (ORCID: https://orcid.org/0000-0001-9828-2541)
- Jelle C. van Dongen (ORCID: https://orcid.org/0000-0003-2505-0066)
- Anja Wagner (ORCID: https://orcid.org/0000-0001-7431-3876)
- Andrew Stubbs (ORCID: https://orcid.org/0000-0001-9817-9982)
- Michail Doukas (ORCID: https://orcid.org/0000-0002-8611-840X)
- Johanna W. Wilmink
- Prof Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
Institutions
- Radboud University Nijmegen (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Amsterdam Neuroscience (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- Meander Medisch Centrum (NL)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-10-19
- DOI
- https://doi.org/10.1016/j.ejca.2025.116065
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00