Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice
Endothelial integrity and endothelial-dependent relaxation depend on age, sex, and segment of the descending thoracic aorta in mice. Genes associated with endothelial-dependent relaxation, endothelial integrity, and vascular aging change markedly by age, including some sex- and segment-specific differences.
Authors
- Lars Saemann (ORCID: https://orcid.org/0000-0003-1516-3286)
- Kristin Wallace (ORCID: https://orcid.org/0000-0002-4297-9064)
- Adrian‐Iustin Georgevici (ORCID: https://orcid.org/0000-0002-2710-2280)
- Gábor Szabó (ORCID: https://orcid.org/0000-0001-6038-9968)
- Shelley Andreas (ORCID: https://orcid.org/0000-0002-5494-7000)
- Hartrumpf Lotta
- Sabine Pohl (ORCID: https://orcid.org/0000-0002-7686-3983)
- Großkopf Anne
- Yuxing Guo (ORCID: https://orcid.org/0000-0002-5786-8391)
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- St. Josef-Hospital (DE)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2025-10-19
- DOI
- https://doi.org/10.1016/j.jmccpl.2025.100491
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00