Comparative Solute–Solvent Interaction of L‐Isoleucine Mixed with Salts Solutions Using Acoustic and Volumetric Properties at 288.15 and 298.15 K

ABSTRACT The physicochemical behavior of L‐Isoleucine in aqueous solutions when two different inorganic electrolytes magnesium nitrate 0.1 m and magnesium sulphate all at the same concentration 0.10 mol/kg are added to the solutions under investigation over the range of concentrations (0.02–0.20 mol/kg) at two temperatures namely 288.15 and 298.15 K in both cases to measure the solutions density (ρ) in 10 mL of specific gravity bottle. Out of these data, a complete set of thermo‐acoustic and volumetric parameters was obtained, viz., adiabatic compressibility (β), nonlinear parameters (B/A), relative association (R A ), and surface tension (Ϭ). The findings are the prominent intermolecular interactions that depend on temperature, the concentration of the solute, and the type of electrolyte. The significant reduction in isothermal compressibility with the rise of the concentration and temperature is evidence of good electrostriction effect and contraction of volume in the binary systems. By comparative analysis, it is clear that L‐Isoleucine + system of Mg(NO 3 ) 2 undergoes greater solute—solvent interaction, which is confirmed by the fact that surface tension values are higher and compressibility is lower. This work offers new insights into the molecular‐level interactions between amino acids and divalent electrolytes, contributing to the understanding of solvation behavior in biomolecular systems. The findings are relevant for macromolecular chemistry, particularly in the design of biomaterials, protein–electrolyte interactions, and pharmaceutical formulations.