CircCdh7 induces astrogliosis and neuroinflammation to trigger hypertensive effects in the rostral ventrolateral medulla
Collectively, our findings demonstrate that elevated circCdh7 expression in the RVLM drives hypertension progression, with the circCdh7/miR-346/Osmr axis serving as a key regulatory mechanism. Targeting circCdh7 may represent a promising therapeutic strategy for hypertension.
Authors
- Dongshu Du (ORCID: https://orcid.org/0000-0003-1198-1089)
- Qiangcheng Zeng
- Shuai Zhang (ORCID: https://orcid.org/0000-0003-2721-8395)
- Xueping Wang (ORCID: https://orcid.org/0000-0002-3010-5685)
- Linping Wang
- Qing He (ORCID: https://orcid.org/0000-0002-1078-350X)
- Bingjie Zhao
- Lei Tong (ORCID: https://orcid.org/0000-0003-2626-4162)
- Tengteng Dai
- Haili Zhang (ORCID: https://orcid.org/0000-0002-7839-4420)
Institutions
- Shanghai University (CN)
- Zhejiang Chinese Medical University (CN)
- Heze Medical College (CN)
- Heze University (CN)
- Dezhou University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-10-19
- DOI
- https://doi.org/10.1186/s13578-025-01480-0
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81