Longitudinal Associations of Multimodal Core 1 Alzheimer Disease Biomarkers With Cognition in Aging and Preclinical Alzheimer Disease
This study demonstrated significant longitudinal associations between multimodal core 1 AD biomarkers and cognitive function over 3 years in CU individuals, including those at the Aβ-negative stage. Distinct biomarker modalities provided complementary insights, emphasizing the potential of blood-based biomarkers for tracking subtle cognitive decline and neuroimaging for delineating vulnerable brain regions in aging and preclinical AD. These findings are crucial for identifying and monitoring high-risk CU individuals, further informing preventive intervention strategies for AD.
Authors
- Marta Milà‐Alomà (ORCID: https://orcid.org/0000-0002-5687-4597)
- Gonzalo Sánchez‐Benavides (ORCID: https://orcid.org/0000-0003-3454-800X)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Anna Brugulat‐Serrat (ORCID: https://orcid.org/0000-0001-8988-5658)
- Mahnaz Shekari (ORCID: https://orcid.org/0000-0003-1336-6768)
- Gemma Salvadó (ORCID: https://orcid.org/0000-0002-5210-9230)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Oriol Grau‐Rivera (ORCID: https://orcid.org/0000-0002-4730-5341)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Carolina Minguillón (ORCID: https://orcid.org/0000-0002-2782-6908)
- David López‐Martos (ORCID: https://orcid.org/0009-0008-1150-2619)
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- Malmö University (SE)
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- Sorbonne Université (FR)
- Pasqual Maragall Foundation (ES)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Hospital Del Mar (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Institut du Cerveau (FR)
- Global Brain Health Institute (US)
- Institute of Neurobiology (BG)
- Northern California Institute for Research and Education (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Neurology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1212/wnl.0000000000214308
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94