Lymphocyte Dynamics and the Emergence of Secondary Autoimmunity Following Immune Reconstitution Therapies in Multiple Sclerosis
A low BL CD4<sup>+</sup> Trte:CD8<sup>+</sup> Temra ratio, accompanied by a sharp relative increase during follow-up, was associated with SAD development. While no definitive associations were found between BL lymphocyte subpopulations and disease activity, a lower CD8<sup>+</sup> T-cell count may suggest an increased risk.
Authors
- Jan Lycke (ORCID: https://orcid.org/0000-0002-7891-8466)
- Igal Rosenstein (ORCID: https://orcid.org/0000-0002-5078-9690)
- Clas Malmeström (ORCID: https://orcid.org/0000-0003-2477-0088)
- Markus Axelsson (ORCID: https://orcid.org/0000-0003-2036-4007)
- Sofia Sandgren (ORCID: https://orcid.org/0000-0001-6206-3339)
- Lenka Novakova (ORCID: https://orcid.org/0000-0001-7899-6395)
Institutions
- Sahlgrenska University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1212/nxi.0000000000200497
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00