An integrated approach of experiment validation and single-cell RNA sequencing reveal dual-pathway inhibition of NLRP3/ferroptosis by flavonoids of Sanyeqing fibrous root in acute lung injury
SYQfr-F ameliorates ALI by concurrently inhibiting NLRP3 inflammasome activation and ferroptosis, validating the traditional use of SYQ in respiratory disorders and highlighting its fibrous roots as a novel therapeutic resource.
Authors
- Jinbao Pu (ORCID: https://orcid.org/0000-0003-4911-1169)
- Lianghui Zhan
- Jie Zhou (ORCID: https://orcid.org/0000-0002-7486-662X)
- Weiqing Liang (ORCID: https://orcid.org/0009-0003-2948-0845)
- Sheng Zhu (ORCID: https://orcid.org/0000-0002-3440-2636)
- Lingling Li (ORCID: https://orcid.org/0000-0002-7280-9592)
- Xuechun Jiang
Institutions
- Zhejiang Chinese Medical University (CN)
- Tongde Hospital of Zhejiang Province (CN)
- Zhejiang Energy Research Institute (CN)
- Zhejiang Energy Group (China) (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.jep.2025.120743
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04