Testing the Immunomodulatory Effects of Probiotic Bacillus coagulans SNZ 1969® in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

<i>B. coagulans</i> SNZ 1969<sup>®</sup> supplementation significantly enhanced NK cell activity and mucosal IgA production in adults, suggesting its potential role in strengthening the innate immune defense mechanisms. These findings support the role of <i>B. coagulans</i> SNZ 1969<sup>®</sup> as a safe dietary supplement for augmenting innate cellular immune function and thereby potentially contributing to a reduced trend to infection susceptibility; however, these preliminary findings require more extensive investigation in a larger study population.

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Publication Details

Journal
Cureus
Published
2025-10-18
DOI
https://doi.org/10.7759/cureus.94845
Primary Topic
Probiotics and Fermented Foods
Type
article
Field-Weighted Citation Impact
0.00
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article

Testing the Immunomodulatory Effects of Probiotic Bacillus coagulans SNZ 1969® in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Kishan PV, Raunak J Soman, Dilip Soman
Cureus
Probiotics and Fermented Foods
article

Testing the Immunomodulatory Effects of Probiotic Bacillus coagulans SNZ 1969® in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Kishan PV, Raunak J Soman, Dilip Soman
article en

Abstract

<i>B. coagulans</i> SNZ 1969<sup>®</sup> supplementation significantly enhanced NK cell activity and mucosal IgA production in adults, suggesting its potential role in strengthening the innate immune defense mechanisms. These findings support the role of <i>B. coagulans</i> SNZ 1969<sup>®</sup> as a safe dietary supplement for augmenting innate cellular immune function and thereby potentially contributing to a reduced trend to infection susceptibility; however, these preliminary findings require more extensive investigation in a larger study population.

CureusVol. 17(10)
Veterans Health Administration (US), Tanvir Hospital (IN)
Openalex Percentile: Top 65%
Probiotics and Fermented Foods
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Testing the Immunomodulatory Effects of Probiotic Bacillus coagulans SNZ 1969® in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial — Kishan PV, Raunak J Soman, et al. · Cureus (2025) | TGRS Research Map | TGRS