Neutrophil extracellular traps drive peritoneal inflammation and tissue remodeling in pediatric peritoneal dialysis
Chronic PD elicits NET-driven sterile inflammation that parallels structural remodeling of the pediatric peritoneum. Supplementing PD fluids with exogenous NET-degrading enzymes may preserve membrane integrity and prolong PD suitability in children.
Authors
- Maria Bartosova (ORCID: https://orcid.org/0000-0003-1127-3453)
- Laia Pagerols Raluy
- Lavinia Schönfeld
- Konrad Reinshagen (ORCID: https://orcid.org/0000-0001-7142-8758)
- Susanne Boettcher
- Claus Peter Schmitt (ORCID: https://orcid.org/0000-0003-4487-3332)
- Raphael Schild
- Martin Herrmann (ORCID: https://orcid.org/0000-0002-0258-2484)
- Michael Boettcher (ORCID: https://orcid.org/0000-0003-4972-9866)
- Charlotte Maria Dücker
- Sarah Bauer-Carmona
Institutions
- Universität Hamburg (DE)
- University of Mannheim (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Pediatric Nephrology
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1007/s00467-025-07003-w
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Baden-Württemberg Stiftung
- Deutsche Forschungsgemeinschaft