Roscovitine alleviates PTSD-like cognitive impairment by inhibiting CDK5-mediated Tau hyperphosphorylation
CDK5-mediated hy-perphosphorylation of Tau at Ser202/Thr205 (AT8) in the hippocampus represents a cru-cial pathological cascade contributing to PTSD cognitive impairments. Early intervention with Rosc shows promising therapeutic potential of PTSD by targeting CDK5.
Authors
- Jinyuan Meng (ORCID: https://orcid.org/0000-0002-1281-8884)
- Mengmeng Chang (ORCID: https://orcid.org/0000-0001-7158-9842)
- Kailu Li (ORCID: https://orcid.org/0000-0002-5364-4155)
- Min Cai
- Kaiwen Xi (ORCID: https://orcid.org/0000-0002-2480-4244)
- Lingxue Zhang
- Gang Zhu (ORCID: https://orcid.org/0000-0001-7575-0058)
- Xiaoyan Wei (ORCID: https://orcid.org/0000-0003-3599-0449)
- Baowen Dong
- Dayun Feng
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111591
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00