Papez circuit remodeling in type 2 diabetes: Enlarged choroid plexus volume partially mediates functional impairments linked to insulin resistance
Our study highlights the complex interplay between Papez circuit functional disruptions, structural atrophy within the circuit, as well as the CPV alterations in T2DM-related cognitive decline. These findings offer potential biomarkers for early detection of cognitive impairments and novel therapeutic targets for intervention in T2DM.
Authors
- Huiyou Chen (ORCID: https://orcid.org/0000-0002-5996-4272)
- Cunnan Mao
- Wenqing Xia (ORCID: https://orcid.org/0000-0003-0830-6779)
- Fengfang Li
- Xindao Yin (ORCID: https://orcid.org/0000-0001-6958-5201)
- Yujie Zhang (ORCID: https://orcid.org/0000-0001-9429-5193)
- Rong Huang (ORCID: https://orcid.org/0000-0002-0836-2845)
- Shuyue Fan (ORCID: https://orcid.org/0000-0003-2865-0737)
- Mingxu Jin (ORCID: https://orcid.org/0000-0002-2340-314X)
- Wen Geng (ORCID: https://orcid.org/0000-0002-5196-7233)
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- NeuroImage
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.neuroimage.2025.121544
- Citations
- 1
- Primary Topic
- Neurological and metabolic disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.29