Rising burden of steatotic liver disease in women of childbearing age and projections to 2035
Metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-related liver disease (ALD) among women of childbearing age are often overlooked despite significant maternal and intergenerational health consequences. Our analysis shows a rising prevalence of MASLD and a modest decline in ALD, with marked regional and socioeconomic disparities, and projects continued MASLD growth through 2035. These findings are important for clinicians, researchers, and policymakers, given the associated maternal, neonatal, and intergenerational risks. Integrating metabolic and reproductive health services alongside equitable policy interventions may help mitigate these concerning trends.
Authors
- Jazleen Leo
- Daniel Q. Huang (ORCID: https://orcid.org/0000-0002-5165-5061)
- Eunice Xiang Xuan Tan (ORCID: https://orcid.org/0000-0001-6194-7933)
- Youxin Wang (ORCID: https://orcid.org/0000-0002-6574-6706)
- R Chen
- Mark Dhinesh Muthiah (ORCID: https://orcid.org/0000-0002-9724-4743)
- Yu Zhou (ORCID: https://orcid.org/0000-0001-5618-7167)
- Cheng Han Ng (ORCID: https://orcid.org/0000-0002-8297-1569)
- Ashok Choudhury (ORCID: https://orcid.org/0000-0003-1591-1715)
- Shi Yan Lee
- Margaret Li Peng Teng (ORCID: https://orcid.org/0000-0001-7472-9214)
Institutions
- Kurume University (JP)
- National University of Singapore (SG)
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Institute of Liver and Biliary Sciences (IN)
- National University Hospital (SG)
- National University Health System (SG)
- Lanzhou University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101646
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00