Probiotics Mitigate High-cholesterol Diet-driven Fatty Liver and Pancreatic Cancer by Restoring Macrophage Homeostasis
The probiotic formulation LR+F15 significantly suppressed HCCD-induced MASLD and PDAC progression partly through suppressing leaky gut and normalizing peritoneal macrophages' inflammatory properties. These findings encourage evaluation of the potential benefits of this probiotic consortium in combination with the existing therapies against PDAC in the future.
Authors
- Salona Kar
- Swayambara Mishra
- Shantibhusan Senapati (ORCID: https://orcid.org/0000-0001-7108-8255)
- Kirti Ranjan Das
- Voddu Suresh (ORCID: https://orcid.org/0000-0001-8533-9465)
- Amlan Priyadarshee Mohapatra
- Deepti Parida
- Supriya Halder
- Manisha Sethi (ORCID: https://orcid.org/0000-0003-2699-7729)
- S Bhagat (ORCID: https://orcid.org/0009-0005-5070-8503)
- Amruta Mohapatra (ORCID: https://orcid.org/0009-0001-1048-6804)
Institutions
- Regional Centre for Biotechnology (IN)
- Institute of Life Sciences (IN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101644
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94