Temporal profiling of myocardial inflammation and recovery in a murine model of cardiac arrest and adrenaline exposure
CA induces a distinct, self-limited myocardial inflammatory cascade that parallels functional cardiac recovery. These findings identify a narrow therapeutic window for immunomodulatory interventions and provide a mechanistic foundation for targeted therapies to mitigate cardiac injury after resuscitation.
Authors
- Soumya Panigrahi (ORCID: https://orcid.org/0000-0002-5024-9459)
- Angela Enriquez
- Shanti R. Tummala (ORCID: https://orcid.org/0000-0003-2428-6771)
- Cody A Rutledge (ORCID: https://orcid.org/0000-0001-7628-2874)
- Donald Rempinski (ORCID: https://orcid.org/0009-0002-3147-7680)
- Kenneth E. Remy (ORCID: https://orcid.org/0000-0001-5222-9884)
- Siyi Jiang (ORCID: https://orcid.org/0000-0002-5481-2771)
Institutions
- University of Pittsburgh (US)
- Louis Stokes Cleveland VA Medical Center (US)
- University of Pittsburgh Medical Center (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Resuscitation Plus
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.resplu.2025.101137
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00