Oxygen-15 Labeled Water Positron Emission Tomography During External Trigeminal Nerve Stimulation
eTNS of bilateral supraorbital nerves (V<sub>1</sub> division) generates significant activations during [<sup>15</sup>O]H<sub>2</sub>O PET imaging in regions associated with major depression and attention deficit disorder. Deactivations of cortical regions including the parahippocampal gyrus, sensorimotor cortex, and others provide a rationale for some of the antiseizure effects of trigeminal nerve stimulation. The results of this study advance our understanding of mechanisms of action of trigeminal nerve stimulation in neuropsychiatric disorders and epilepsy.
Authors
- Daniel Silverman (ORCID: https://orcid.org/0000-0002-3502-3742)
- Mary K.W. Susselman
- Christopher M. DeGiorgio (ORCID: https://orcid.org/0000-0002-9863-9069)
- Lara M. Schrader
- Patrick Miller (ORCID: https://orcid.org/0000-0002-9301-4780)
- Ian A. Cook (ORCID: https://orcid.org/0000-0002-8991-3804)
- Cheri Geist
Institutions
- University of California, Los Angeles (US)
Publication Details
- Journal
- Neuromodulation Technology at the Neural Interface
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.neurom.2025.06.017
- Primary Topic
- Trigeminal Neuralgia and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00