Melatonin attenuates cardiac oxidative stress in diabetic rats following acute exhaustive exercise
Our findings demonstrate that melatonin confers antioxidant protection to the diabetic heart, primarily by increasing glutathione levels and attenuating lipid peroxidation. This establishes a protective state that enhances cardiac resilience, and the combination of melatonin and exercise may offer synergistic benefits against acute, stress-induced oxidative damage in diabetic animals.
Authors
- Rafael Herling Lambertucci (ORCID: https://orcid.org/0000-0001-8532-2639)
- Cristiano Mendes da Silva
- Elaine Hatanaka (ORCID: https://orcid.org/0000-0002-9716-1163)
- Rafael Ishihara Figueirôa
- Gary Sweeney (ORCID: https://orcid.org/0000-0002-1946-1347)
- Carol Nguyen
Institutions
- York University (CA)
- Universidade Cruzeiro do Sul (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Cell Stress and Chaperones
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.cstres.2025.100126
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00