Association between sickle cell trait and Plasmodium falciparum infection: evidence for age-specific protection in a cross-sectional study in Guinea-Bissau
SCT offered protection against severe outcomes among young children but increased microscopic infection risk among older individuals, underscoring the paradox and complexity of SCT-mediated protective mechanisms and their relevance for host-targeted malaria elimination strategies.
Authors
- Márcia Melo Medeiros (ORCID: https://orcid.org/0000-0002-5364-9087)
- Ronise Silva (ORCID: https://orcid.org/0000-0002-5799-323X)
- Amabélia Rodrigues (ORCID: https://orcid.org/0000-0002-7976-1157)
- Ana Paula Arez (ORCID: https://orcid.org/0000-0002-0497-6532)
Institutions
- Bandim Health Project (GW)
- Instituto de Medicina Tropical (PY)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.ijid.2025.108135
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação para a Ciência e a Tecnologia