Comparative evaluation of a multiplex polymerase chain reaction panel for high-consequence infectious diseases against conventional diagnostics in travelers with febrile diseases
The multiplex PCR detected pathogens from blood with varying levels of specificity and sensitivity in less than 1 hour. For HCID, it could shorten the time to diagnosis. However, Salmonella enterica spp. or Leptospira spp. were detected infrequently.
Authors
- Timo Wolf (ORCID: https://orcid.org/0000-0002-3819-9540)
- Markus Eickmann
- Stefan Metz (ORCID: https://orcid.org/0000-0002-9249-2844)
- Sandra Ciesek (ORCID: https://orcid.org/0000-0002-1802-7565)
- Johanna Kessel (ORCID: https://orcid.org/0000-0003-3246-5219)
- Michael Hogardt (ORCID: https://orcid.org/0000-0002-0742-950X)
- Frauke Borgans
- Niko Kohmer (ORCID: https://orcid.org/0000-0002-5458-1467)
- Raja Idris (ORCID: https://orcid.org/0009-0004-1565-5859)
- T. Appel
- Rabenau Hf
- Vehreschild Mjgt
- Zielbauer As
- R Golbach
Institutions
- Goethe University Frankfurt (DE)
- Philipps University of Marburg (DE)
- University Hospital Frankfurt (DE)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.ijid.2025.108147
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00