Gonadal Genetics and Germ Cell Tumor Risk in SRY-Negative 46,XX Testicular/Ovotesticular Disorders of Sex Development

The risk of GCTs in individuals with SRY-negative 46,XX testicular and ovotesticular DSD remains contentious. This study underscores the importance of comprehensive genetic and histological evaluations of gonadal tissues. Immunohistochemical findings suggest a relatively low GCT risk; however, long-term follow-up is essential for effective patient monitoring.

Authors

Hongjuan Tian (ORCID: https://orcid.org/0000-0002-1109-8547)
Daxing Tang (ORCID: https://orcid.org/0000-0003-2103-4931)
Dehua Wu (ORCID: https://orcid.org/0000-0003-0560-0016)
Junfen Fu (ORCID: https://orcid.org/0000-0001-6405-1251)
Hao Yang (ORCID: https://orcid.org/0000-0003-3834-4346)
Weizhong Gu

Institutions

Children's Hospital of Zhejiang University (CN)

Publication Details

Journal: Hormone Research in Paediatrics
Published: 2025-10-18
DOI: https://doi.org/10.1159/000548934
Primary Topic: Sexual Differentiation and Disorders
Type: article
Field-Weighted Citation Impact: 0.00

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

Gonadal Genetics and Germ Cell Tumor Risk in SRY-Negative 46,XX Testicular/Ovotesticular Disorders of Sex Development

Hongjuan Tian, Daxing Tang, Dehua Wu, Junfen Fu et al.

Oct 18, 2025

Hormone Research in Paediatrics

Sexual Differentiation and Disorders

article

Gonadal Genetics and Germ Cell Tumor Risk in SRY-Negative 46,XX Testicular/Ovotesticular Disorders of Sex Development

Hongjuan Tian, Daxing Tang, Dehua Wu, Junfen Fu, Hao Yang, Weizhong Gu

October 18, 2025article en

Abstract

The risk of GCTs in individuals with SRY-negative 46,XX testicular and ovotesticular DSD remains contentious. This study underscores the importance of comprehensive genetic and histological evaluations of gonadal tissues. Immunohistochemical findings suggest a relatively low GCT risk; however, long-term follow-up is essential for effective patient monitoring.

Hormone Research in Paediatrics

Children's Hospital of Zhejiang University (CN)

Openalex Percentile: Top 74%

Sexual Differentiation and Disorders

DOI Source OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.