Spatial profiling of giant cell arteritis tissues reveals immune heterogeneity and potential predictors of glucocorticoid response
Our findings reveal an immunopathologic signature in GCA at diagnosis, characterised by plasma cell-rich infiltrates associated with favourable outcomes, and ECM- and T cell-associated inflammation enriched in GC-refractory cases. These insights could foster a precision medicine approach to GCA management, enabling patient stratification for GC-sparing therapies and optimising patient outcomes.
Authors
- Samuel McAllister (ORCID: https://orcid.org/0000-0002-2179-5303)
- Robert J. Benschop (ORCID: https://orcid.org/0000-0001-6313-5218)
- Lisa C. Hutton
- Carl S. Goodyear (ORCID: https://orcid.org/0000-0001-5926-5941)
- David C Gemperline
- Aysın Tulunay Virlan (ORCID: https://orcid.org/0000-0003-4735-9902)
- John Cole (ORCID: https://orcid.org/0000-0002-6386-766X)
- Ajay Nirula
- Ishita Gupta (ORCID: https://orcid.org/0000-0002-5101-6876)
- Holly Leslie (ORCID: https://orcid.org/0000-0001-8898-3600)
- Neil Basu (ORCID: https://orcid.org/0000-0003-4246-3145)
- Iain B. McInnes (ORCID: https://orcid.org/0000-0002-6462-4280)
- Nigel B. Jamieson (ORCID: https://orcid.org/0000-0002-9552-4725)
- Lin Zhang (ORCID: https://orcid.org/0000-0002-2157-1588)
- Evelyn Qian (ORCID: https://orcid.org/0000-0001-7709-2175)
- Maria Laura Vieri (ORCID: https://orcid.org/0000-0002-7309-0647)
- Cecilia Ansalone (ORCID: https://orcid.org/0000-0001-8683-1718)
- Dominic McGovern (ORCID: https://orcid.org/0000-0003-3127-2052)
- Isabella H. Wulur
- Sylvia Wright (ORCID: https://orcid.org/0000-0002-0810-3915)
- Yoana Doncheva
- Claire Kennedy Dietrich
- A. C. S. Peacock
- Paul Cauchi
- Timothy Beckman
- Ethan S Pickerill
- Victoria Kellior
Institutions
- Eli Lilly (United States) (US)
- NHS Greater Glasgow and Clyde (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.ard.2025.09.009
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company