The effects of balanced crystalloid versus plasma on endothelial injury, systemic inflammation, and coagulation in experimental endotoxaemia: a randomised human volunteer study
In human endotoxaemia, plasma resuscitation reduced leucocyte and neutrophil levels but did not reduce glycocalyx degradation, when compared with equal volume resuscitation with a balanced crystalloid solution.
Authors
- Karen Vanhoorelbeke (ORCID: https://orcid.org/0000-0003-2288-8277)
- Philip Charles Spinella (ORCID: https://orcid.org/0000-0003-1721-0541)
- Robert B. Klanderman
- Derek J. B. Kleinveld (ORCID: https://orcid.org/0000-0002-6357-1471)
- Daan P. van den Brink (ORCID: https://orcid.org/0000-0003-0552-3225)
- Inge Pareyn (ORCID: https://orcid.org/0000-0003-0602-0929)
- Nicole P. Juffermans (ORCID: https://orcid.org/0000-0002-3039-6574)
- Bashar N. Hilderink
Institutions
- University of Pittsburgh (US)
- Institute for Transfusion Medicine (US)
- Research Institute for Chromatography (BE)
- Amsterdam Neuroscience (NL)
- International New Town Institute (NL)
- C Care Orthopedics (NL)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
- Rotterdam University of Applied Sciences (NL)
- Erasmus University Rotterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- British Journal of Anaesthesia
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.bja.2025.08.060
- Citations
- 1
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 1.55