Efficacy of topical Ivermectin in controlling human Demodex infestation: Evidence from systematic review and meta-analysis

Topical ivermectin is effective and well-tolerated for reducing the number and density of <i>Demodex</i> mites. A 16-week treatment course significantly decreases mite burden and improves clinical outcomes with minimal adverse events. However, the potential for mite repopulation after treatment underscores the importance of ongoing monitoring. Study heterogeneity and the limited number of included trials warrant cautious interpretation of the findings.