Synthesis, computational, and biological evaluation of novel indolophenyl carboxamides as potential antimalarial agents
Compounds 1, 7, 8, and 9 showed potent antimalarial activity against Pf3D7 and Pf C580Y with IC<sub>50</sub> values of 8.9 and 3.4 µM, 5.5 and 2.2 µM, 10.1 and 14.0 µM, and 12.2 and 28.6 µM, respectively, and were nontoxic to human cells. Further, in silico studies confirmed Plasmodium dihydrofolate reductase as the target of indolophenyl carboxamides. This study identifies indolophenyl carboxamides, including bisindole, as promising new antimalarial agents effective against sensitive and drug-resistant <i>P. falciparum</i>.
Authors
- Gautam Kumar (ORCID: https://orcid.org/0000-0003-4047-1416)
- Priya Mondal (ORCID: https://orcid.org/0000-0003-1909-5487)
- Kapil Vashisht (ORCID: https://orcid.org/0000-0003-0550-0162)
- N. K. Tiwari (ORCID: https://orcid.org/0000-0002-3153-2531)
- Asha Kiran Tudu (ORCID: https://orcid.org/0009-0009-6354-0999)
- Rahul Kumar (ORCID: https://orcid.org/0000-0002-3603-7572)
- Kailash C. Pandey (ORCID: https://orcid.org/0000-0003-3936-4357)
- Priyanka Rani (ORCID: https://orcid.org/0009-0003-0852-6170)
- Supriya Sharma (ORCID: https://orcid.org/0009-0009-0223-9289)
- Tanish
Institutions
- National Institute of Pharmaceutical Education and Research - Ahmedabad (IN)
- National Institute of Pharmaceutical Education and Research (IN)
- Birla Institute of Technology and Science, Pilani (IN)
- National Institute of Malaria Research (IN)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1080/17568919.2025.2575755
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00