Varied Patterns of Decay of Intact Human Immunodeficiency Virus Type 1 Proviruses Over 2 Decades of Antiretroviral Therapy
Fourteen people with human immunodeficiency virus type 1 had longitudinal measurements of intact, defective, and total proviral DNA over the course of two decades of antiretroviral therapy. Three patterns of intact proviral DNA decay were revealed: (1) biphasic decline with markedly slower second-phase decline, (2) initial decline that transitions to a zero-slope plateau, and (3) initial decline followed by later increases in intact proviral DNA. Defective proviral DNA levels were essentially stable. Mechanisms of slowing or reversal of second-phase decay of intact proviral DNA may include the inability to clear cells with intact but transcriptionally silent proviruses and clonal expansion of cells with intact proviruses.
Authors
- Sharon A. Riddler (ORCID: https://orcid.org/0000-0002-2545-7037)
- Laura Hovind
- Joseph J. Eron (ORCID: https://orcid.org/0000-0002-4938-0644)
- Deborah K. McMahon (ORCID: https://orcid.org/0000-0002-4374-3539)
- Albine Martin
- Ronald J. Bosch (ORCID: https://orcid.org/0000-0002-1774-4140)
- Hanna Mar
- John W. Mellors (ORCID: https://orcid.org/0000-0002-3737-9742)
- Rajesh T. Gandhi (ORCID: https://orcid.org/0000-0002-9701-6062)
- Elias K. Halvas (ORCID: https://orcid.org/0000-0002-4890-1209)
- Joshua C. Cyktor (ORCID: https://orcid.org/0000-0003-3601-4837)
- Kristen D. Ritter
- Gregory M. Laird (ORCID: https://orcid.org/0000-0003-2873-4295)
- Ann C. Collier (ORCID: https://orcid.org/0000-0001-5673-0422)
- and the SAPALDIA Team
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2025-09-24
- DOI
- https://doi.org/10.17615/ktbb-0c72
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00