Stable Latent HIV Infection and Low-level Viremia Despite Treatment With the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat
We tested the combination of a broadly neutralizing HIV antibody with the latency reversal agent vorinostat (VOR). Eight participants received 2 month-long cycles of VRC07-523LS with VOR. Low-level viremia, resting CD4+ T-cell-associated HIV RNA (rca-RNA) was measured, and intact proviral DNA assay (IPDA) and quantitative viral outgrowth assay (QVOA) were performed at baseline and posttreatment. In 3 participants, IPDA and QVOA declines were accompanied by significant declines of rca-RNA. However, no IPDA or QVOA declines clearly exceeded assay variance or natural decay. Increased resistance to VRC07-523LS was not observed. This combination therapy did not reduce viremia or the HIV reservoir. Clinical Trials Registration. NCT03803605.
Authors
- Adrian B. McDermott (ORCID: https://orcid.org/0000-0003-0616-9117)
- Samuel L M Raines
- David C. Montefiori (ORCID: https://orcid.org/0000-0003-0856-6319)
- Shane D. Falcinelli (ORCID: https://orcid.org/0000-0002-3554-226X)
- David M. Margolis (ORCID: https://orcid.org/0000-0001-5714-0002)
- Michelle Floris-Moore (ORCID: https://orcid.org/0009-0007-9515-2857)
- Jennifer Kirchherr (ORCID: https://orcid.org/0000-0003-3559-7356)
- JoAnn Kuruc (ORCID: https://orcid.org/0000-0001-8874-8950)
- Robert J. Gorelick (ORCID: https://orcid.org/0000-0002-1773-9085)
- Richard A. Koup (ORCID: https://orcid.org/0000-0002-3090-7282)
- Joseph J. Eron (ORCID: https://orcid.org/0000-0002-4938-0644)
- Nancie M. Archin (ORCID: https://orcid.org/0000-0002-7938-0389)
- Marina Tuyishime (ORCID: https://orcid.org/0000-0002-6940-3639)
- Cynthia L. Gay (ORCID: https://orcid.org/0000-0002-3620-3059)
- Guido Ferrari (ORCID: https://orcid.org/0000-0001-7747-3349)
- Xiaoying Shen (ORCID: https://orcid.org/0000-0002-8387-3952)
- Matthew Moeser (ORCID: https://orcid.org/0000-0002-1368-5171)
- Sarah Joseph (ORCID: https://orcid.org/0000-0001-9603-574X)
- Katherine S. James (ORCID: https://orcid.org/0000-0002-5854-8787)
- Brigitte Allard
- Lúcio Gama (ORCID: https://orcid.org/0000-0001-9511-012X)
- John R. Mascola (ORCID: https://orcid.org/0000-0002-5293-4695)
- Matthew L. Clohosey (ORCID: https://orcid.org/0000-0002-5986-057X)
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2025-09-24
- DOI
- https://doi.org/10.17615/0mmz-dm17
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00