Whose Line Is it Anyway? Defining Seropositivity Cutoffs for Infectious Disease Surveillance
We advocate for a context-dependent, evidence-based selection of cut-off methodologies, informed by panels of confirmed positive and negative samples. As multiplex serological platforms become increasingly central to integrated disease surveillance, robust frameworks for interpreting antibody data are needed. Our proposed framework offers a pragmatic path forward, bridging immunological theory and statistical rigor to improve the reliability and comparability of sero-epidemiological insights across diverse epidemiological settings.
Authors
- Fatoumata Diène Sarr
- Stéphane Pelleau (ORCID: https://orcid.org/0000-0002-7070-2177)
- Cheikh Sokhna (ORCID: https://orcid.org/0000-0003-4810-8232)
- Françoise Donnadieu
- Hubert Bassène (ORCID: https://orcid.org/0000-0001-6507-1764)
- Michael White (ORCID: https://orcid.org/0000-0002-7472-4138)
- Arona Sabène Diatta
- Makhtar Niang (ORCID: https://orcid.org/0000-0003-0810-4595)
- Inès Vigan-Womas (ORCID: https://orcid.org/0000-0001-7848-9297)
- Aïssatou Touré-Baldé (ORCID: https://orcid.org/0000-0003-0090-9495)
- Gaëlle Baudemont (ORCID: https://orcid.org/0009-0006-0345-7489)
- Ibrahima Sarr
- Joseph Faye
- Aissatou Diagne (ORCID: https://orcid.org/0009-0007-0130-3184)
Institutions
- Inserm (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Institut de Recherche pour le Développement (SN)
- Institut Pasteur de Dakar (SN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1093/infdis/jiaf537
- Citations
- 2
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Agence Nationale de la Recherche
- Centers for Disease Control and Prevention