Comparison of Dual- versus Triple-Targeted Drug Therapy for Patients with Left-To-Right Shunt Congenital Heart Disease-Associated Pulmonary Arterial Hypertension

Combination targeted therapy is effective for patients with left-to-right shunt CHD-PAH, regardless of closure status. Among patients not eligible for closure, triple-targeted therapy demonstrated superior efficacy compared to dual-targeted therapy.

Authors

Lifan Yang (ORCID: https://orcid.org/0000-0003-0581-1964)
Dandan Chen (ORCID: https://orcid.org/0000-0002-7690-4837)
Hao Li (ORCID: https://orcid.org/0000-0002-8644-0263)
Junbo Ge (ORCID: https://orcid.org/0000-0002-9360-7332)
Wenzhi Pan

Institutions

Sun Yat-sen University (CN)
Fudan University (CN)
Shanghai Xuhui Central Hospital (CN)
Zhongshan Hospital (CN)
The First Affiliated Hospital, Sun Yat-sen University (CN)
Shanghai Clinical Research Center (CN)
YangPu Geriatric Hospital (CN)

Publication Details

Journal: Cardiology
Published: 2025-10-17
DOI: https://doi.org/10.1159/000548907
Primary Topic: Pulmonary Hypertension Research and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Comparison of Dual- versus Triple-Targeted Drug Therapy for Patients with Left-To-Right Shunt Congenital Heart Disease-Associated Pulmonary Arterial Hypertension

Lifan Yang, Dandan Chen, Hao Li, Junbo Ge et al.

Oct 17, 2025

Cardiology

Pulmonary Hypertension Research and Treatments

article

Comparison of Dual- versus Triple-Targeted Drug Therapy for Patients with Left-To-Right Shunt Congenital Heart Disease-Associated Pulmonary Arterial Hypertension

Lifan Yang, Dandan Chen, Hao Li, Junbo Ge, Wenzhi Pan

October 17, 2025article en

Abstract

Combination targeted therapy is effective for patients with left-to-right shunt CHD-PAH, regardless of closure status. Among patients not eligible for closure, triple-targeted therapy demonstrated superior efficacy compared to dual-targeted therapy.

Cardiology

Sun Yat-sen University (CN), Fudan University (CN), Shanghai Xuhui Central Hospital (CN), Zhongshan Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Shanghai Clinical Research Center (CN), YangPu Geriatric Hospital (CN)

Openalex Percentile: Top 58%

Pulmonary Hypertension Research and Treatments

DOI Source OpenAlex

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Comparison of Dual- versus Triple-Targeted Drug Therapy for Patients with Left-To-Right Shunt Congenital Heart Disease-Associated Pulmonary Arterial Hypertension — Lifan Yang, Dandan Chen, et al. · Cardiology (2025) | TGRS Research Map | TGRS