<i>ZC3H13</i> Loss Drives Cancer Metastatic Progression by Disrupting m6A RNA Methylation
FDA-approved m6A demethylase inhibitors can inhibit metastasis driven by ZC3H13 deficiency, which reduces m6A methylation of select transcripts involved in migration and invasion, providing potential therapeutic options for patients with metastatic cancer.
Authors
- Óscar Monteagudo-García (ORCID: https://orcid.org/0000-0002-3992-5786)
- Diego Alonso‐López (ORCID: https://orcid.org/0000-0003-1015-9923)
- Sandra Blanco (ORCID: https://orcid.org/0000-0001-7352-9392)
- Elena S. Martens‐Uzunova (ORCID: https://orcid.org/0000-0002-5363-2525)
- Guido Jenster (ORCID: https://orcid.org/0000-0002-8658-2552)
- Ángel Román (ORCID: https://orcid.org/0000-0002-5868-6768)
- Paz Nombela (ORCID: https://orcid.org/0000-0003-2730-3397)
- Cármen Jerónimo (ORCID: https://orcid.org/0000-0003-4186-5345)
- Devi Prasad Bhattarai (ORCID: https://orcid.org/0000-0001-9659-4613)
- Berta Casar (ORCID: https://orcid.org/0000-0002-3058-5631)
- Diana Loa-Mesón
- Rui Henrique (ORCID: https://orcid.org/0000-0003-3171-4666)
- Daniela Barros‐Silva (ORCID: https://orcid.org/0000-0001-6746-6807)
- Francesca Aguiló (ORCID: https://orcid.org/0000-0002-2374-2045)
- Vicente Fernández-Rodero
Institutions
- Universidade do Porto (PT)
- Universidad de Salamanca (ES)
- Erasmus MC (NL)
- Instituto de Biomedicina y Biotecnología de Cantabria (ES)
- Instituto Português de Oncologia Francisco Gentil (PT)
- IPO Porto (PT)
- Instituto de Investigación Biomédica de Salamanca (ES)
- National Research Council (LK)
- Centro de Investigación del Cáncer (ES)
- Erasmus MC Cancer Institute (NL)
- Universidad de Extremadura (ES)
- Umeå University (SE)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3975
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00