The Bidirectional Casual Relationships between Chronic Inflammation and Intrinsic Capacity Decline: Insights from Mendelian Randomization Analysis

Our study provides robust evidence for bidirectional causal relationships between chronic inflammation and intrinsic capacity decline, highlighting inflammation as a potential target for interventions to promote healthy aging. Future research is required to explore these relationships in more diverse populations and investigate therapeutic strategies to mitigate inflammation-related declines in intrinsic capacity.