Targeting CD14 to Inhibit Macrophage Senescence and Regulate the Microenvironment for Enhanced Tendon-Bone Healing
Currently, targeted therapeutics to enhance tendon-bone healing post-ACLR are lacking in clinical practice. The findings demonstrate that microenvironmental inflammation leading to macrophage senescence is a critical factor contributing to impaired tendon-bone healing. CD14-targeted therapy may inhibit macrophage senescence, accelerate tendon-bone healing, and offer significant translational potential for clinical application.
Authors
- Jihua Li (ORCID: https://orcid.org/0000-0001-8651-3840)
- Juncheng Yao (ORCID: https://orcid.org/0000-0001-9490-4577)
- Denghui Xie (ORCID: https://orcid.org/0000-0001-5414-3152)
- Shuang Cong (ORCID: https://orcid.org/0000-0001-8101-0128)
- Huabin Chen (ORCID: https://orcid.org/0000-0002-6263-7002)
- Yan Shao (ORCID: https://orcid.org/0000-0001-6940-671X)
- Xuan Wang (ORCID: https://orcid.org/0000-0002-0790-5641)
- J K Zhang (ORCID: https://orcid.org/0000-0001-7132-8247)
- Yuhao Wu (ORCID: https://orcid.org/0009-0008-7564-1458)
- Chun Zeng (ORCID: https://orcid.org/0000-0002-5682-1452)
- Daozhang Cai
- Lan Xu
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
Publication Details
- Journal
- The American Journal of Sports Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1177/03635465251383161
- Citations
- 2
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 4.01