Glymphatic system dysfunction associated with player position in collegiate American football players: A DTI-ALPS study
These findings indicate that positional differences in HAEs experienced by Speed players, even absent clinical concussion, may contribute to impaired glymphatic function. Speed position players may be at increased risk due to the nature and magnitude of head impacts. The DTI-ALPS index may serve as a sensitive biomarker for early, sub-clinical brain dysfunction in athletes participating in contact sports.
Authors
- Semyon Slobounov
- Michael Gay
- Kevin M. Cockroft (ORCID: https://orcid.org/0000-0002-7456-7507)
- Linda Papa (ORCID: https://orcid.org/0000-0002-1175-3839)
- Wayne J. Sebastianelli (ORCID: https://orcid.org/0000-0003-0153-5907)
- Krishnamoorthy Thamburaj (ORCID: https://orcid.org/0000-0002-6488-2861)
- Xiaoxiao Bai (ORCID: https://orcid.org/0000-0001-5369-5772)
- Owen W. Griffith
Institutions
- Oklahoma State Department of Health (US)
- Pennsylvania State University (US)
- Orlando Health (US)
- University Orthopedics Center (US)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Neuroimage Reports
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1016/j.ynirp.2025.100295
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00