Clinical and genetic characteristics of patients diagnosed with atypical hemolytic uremic syndrome (aHUS): epidemiological data from the Belgian cohort of the Global aHUS Registry
This study strengthens the real-world evidence on aHUS and adds to previously published Global aHUS Registry data. In addition, it provides insights into the differential epidemiology of the disease in Belgium and demonstrates the increased susceptibility of women to aHUS across the whole spectrum of recognized complement gene variants.
Authors
- Éric Goffin (ORCID: https://orcid.org/0000-0001-9242-7148)
- Evelien Snauwaert (ORCID: https://orcid.org/0000-0003-2660-7460)
- Karin Dahan (ORCID: https://orcid.org/0000-0003-3036-7981)
- Annick Massart (ORCID: https://orcid.org/0000-0002-6196-8555)
- Patrick Stordeur (ORCID: https://orcid.org/0000-0001-5398-0709)
- K. van Hoeck
- Laure Collard (ORCID: https://orcid.org/0000-0003-3073-8201)
- Johan Vande Walle (ORCID: https://orcid.org/0000-0001-9700-5358)
- Laurent Weekers (ORCID: https://orcid.org/0000-0002-3151-4640)
- Djalila Mekahli (ORCID: https://orcid.org/0000-0003-0954-6088)
- Kathleen Claes (ORCID: https://orcid.org/0000-0001-8510-2345)
- Stefan Van Cauwelaert (ORCID: https://orcid.org/0000-0002-4418-2817)
- Imad Al‐Dakkak (ORCID: https://orcid.org/0000-0002-0804-998X)
- Tess Van Meerhaeghe (ORCID: https://orcid.org/0000-0002-9018-9278)
- Nathalie Godefroid (ORCID: https://orcid.org/0000-0002-7354-4741)
- Brigitte Adams (ORCID: https://orcid.org/0000-0001-9693-2205)
- Stan L. Block
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Université Libre de Bruxelles (BE)
- University of Liège (BE)
- Ghent University Hospital (BE)
- Erasmus Hospital (BE)
- Centre Hospitalier Chrétien (BE)
- Institute of Pathology and Genetics (BE)
- Antwerp University Hospital (BE)
- Queen Fabiola Children's University Hospital (BE)
- Alexion Pharmaceuticals (United States) (US)
- Universitair Ziekenhuis Brussel (BE)
- Centre Hospitalier Universitaire de Liège (BE)
- Alexion Pharma (Switzerland) (CH)
- UCLouvain (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Nephrology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1007/s40620-025-02366-7
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alexion Pharmaceuticals
- Akershus Universitetssykehus