Crosstalk between tumor endothelial cells and cancer cells is important for metastasis initiation
Our results demonstrate that crosstalk between cancer cells and TEC, partly through angiocrine factors in the TME, induces the rate-limiting steps of metastasis initiation.
Authors
- João Roque (ORCID: https://orcid.org/0000-0002-1191-4997)
- Leonor Rib (ORCID: https://orcid.org/0000-0001-8862-195X)
- Joana Leitão-Castro (ORCID: https://orcid.org/0000-0003-2705-9072)
- Janine T. Erler (ORCID: https://orcid.org/0000-0001-8675-6527)
- Mia K. Høg
- Flemming Steen Jørgensen (ORCID: https://orcid.org/0000-0001-8040-2998)
- Kasper Johansen Mygind (ORCID: https://orcid.org/0009-0004-4438-9019)
- Victor Oginga Oria (ORCID: https://orcid.org/0000-0001-7187-7916)
- Marie Vestergaard Lukassen (ORCID: https://orcid.org/0000-0003-3237-2696)
- Alejandro Martínez (ORCID: https://orcid.org/0000-0002-7601-5642)
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12964-025-02441-3
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Danmarks Tekniske Universitet