Bioinformatics based exploration of the anti-liver fibrosis mechanism of Pien Tze Huang via EGFR/JAK1/STAT3 pathway
The findings reveal that PZH ameliorates liver fibrosis by inhibiting macrophage-mediated inflammation via blockade of the EGFR/JAK1/STAT3 signaling axis, providing a mechanistic foundation for its clinical application.
Authors
- Fan Lin (ORCID: https://orcid.org/0000-0002-1372-0256)
- Xiaoting Hong (ORCID: https://orcid.org/0000-0002-2420-4257)
- Min Zheng (ORCID: https://orcid.org/0000-0002-0329-9680)
- Yuqin Zhang (ORCID: https://orcid.org/0000-0002-4872-0889)
- Chunfeng Lin
- Xu Wei (ORCID: https://orcid.org/0000-0002-2395-2608)
- Lixin Huang (ORCID: https://orcid.org/0000-0002-8507-1910)
- Haiyin Zheng
- Qing Xiong (ORCID: https://orcid.org/0000-0002-8656-2041)
- Yonghua Ye
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1665648
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35