Proton boron capture therapy: microdosimetry and treatment planning study with boron
These findings indicate that PBCT can induce detectable increases in microdosimetric lineal energy under high-energy proton beams, even in the absence of macroscopic dose enhancement. The treatment planning results further highlight the potential of boron-enhanced LET modulation in conjunction with FLASH delivery. Together, the study supports continued investigation of PBCT as a strategy to optimize biological effectiveness in proton therapy, with future work focusing on realistic boron distribution models and integration of dose-rate effects.
Authors
- Ilya Sedliarou (ORCID: https://orcid.org/0000-0002-0001-2568)
- Kerry Han (ORCID: https://orcid.org/0000-0001-7997-2037)
- Eun Ho Kim
- Wen Shen Looi (ORCID: https://orcid.org/0000-0002-4791-3670)
- Seung‐Hoon Yoo (ORCID: https://orcid.org/0000-0001-5048-219X)
- Ru Xin Wong
- Anatoly Rosenfeld (ORCID: https://orcid.org/0000-0001-5116-6308)
- Yen Hwa Lin (ORCID: https://orcid.org/0000-0001-5268-5951)
- Kum Bae Kim (ORCID: https://orcid.org/0000-0002-9672-2424)
- Himanshu Brahmbhatt (ORCID: https://orcid.org/0000-0003-4796-9890)
- Linh T. Tran (ORCID: https://orcid.org/0000-0002-3321-2611)
- Jennifer A. MacDiarmid (ORCID: https://orcid.org/0000-0003-0394-9521)
- W. Tan
- Soorim Han (ORCID: https://orcid.org/0000-0002-6678-6849)
- S. Ho
- Ying Ying Cheah
- Paul Yeo
- SK Djeng
Institutions
- Advantest (Singapore) (SG)
- Yonsei University (KR)
- University of Wollongong (AU)
- Daegu Catholic University (KR)
- Korea Institute of Radiological and Medical Sciences (KR)
- Daegu Catholic University Medical Center (KR)
- Engeneic (Australia) (AU)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fonc.2025.1615241
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00