Therapeutic potential of Glycyrrhiza polysaccharides in pseudorabies virus infection: immune modulation, antioxidant activity, and gut microbiota restoration
GPs exert protective effects against PRV-induced intestinal injury by modulating immune and oxidative responses, enhancing mucosal barrier integrity, and rebalancing gut microbiota. These findings support the potential of GPs as a therapeutic agent for viral enteric diseases. To our knowledge, this is the first study to demonstrate the protective role of GPs against PRV infection <i>in vivo</i>. These findings expand current understanding of the antiviral potential of plant-derived polysaccharides and highlight GPs as a promising candidate for the development of novel polysaccharide-based therapeutics for viral enteric diseases.
Authors
- Dengyu Pan (ORCID: https://orcid.org/0000-0002-2398-0537)
- Xianghua Shu (ORCID: https://orcid.org/0000-0002-3172-2693)
- Hongqiang Shen (ORCID: https://orcid.org/0000-0001-7188-5289)
- Chunlian Song (ORCID: https://orcid.org/0000-0001-5710-9718)
- Zhihui Zhang (ORCID: https://orcid.org/0000-0003-3111-2665)
- Shanshan Yang (ORCID: https://orcid.org/0000-0003-3729-7795)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-7141-2374)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-9900-7568)
- Qianfei Wei
Institutions
- Yunnan Agricultural University (CN)
- Animal Husbandry & Veterinary (IN)
- Animal Husbandry and Veterinary Department (IN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fvets.2025.1679013
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00