Total Syntheses of Sappanin‐Based Natural Products Enabled by Pattern Recognition Analysis and Brominative Aromatization
Described is a concise route to caesappins A and B, urolithin C, and protosappanin A, which share a common sappanin core. An arylation of a cyclic vinylogous ester and a brominative aromatization were applied to construct a privileged intermediate, which was subsequently converted to the target natural products through strategic coupling reactions.
Authors
- Jingyu Liang
- Yen‐Ku Wu (ORCID: https://orcid.org/0000-0002-9269-7444)
- Weiting Zhao (ORCID: https://orcid.org/0009-0005-6816-3863)
Institutions
- National Yang Ming Chiao Tung University (TW)
- Chung Yuan Christian University (TW)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1002/asia.202500886
- Primary Topic
- Biological Stains and Phytochemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council