Modest radiation dose escalation for early-stage anal cancer: cancer control and toxicity outcomes
Modest dose escalation was not associated with improved FFLR among patients with T1-2N0 SCCA; however, it was associated with worse acute GU and pain toxicity. Future efforts should focus on biomarkers to identify patients who may potentially benefit from treatment escalation.
Authors
- Michael Kevin Rooney (ORCID: https://orcid.org/0000-0002-2860-4653)
- Emma B. Holliday (ORCID: https://orcid.org/0000-0002-4362-461X)
- Ethan B. Ludmir (ORCID: https://orcid.org/0000-0002-5472-5344)
- Eugene J. Koay (ORCID: https://orcid.org/0000-0001-7675-3461)
- Sonal S. Noticewala (ORCID: https://orcid.org/0000-0002-3153-0317)
- Grace L. Smith (ORCID: https://orcid.org/0000-0002-3171-2911)
- Sage Copling (ORCID: https://orcid.org/0000-0003-2671-6317)
- Prajnan Das (ORCID: https://orcid.org/0000-0002-8253-4190)
- Bruce D. Minsky (ORCID: https://orcid.org/0000-0001-8434-7930)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas Health Science Center (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fonc.2025.1637205
- Primary Topic
- Colorectal and Anal Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00