Integrating single-cell transcriptomics and whole-genome CRISPR CAS9 screen identifies a cell cluster associated with tumor dependency in triple-negative breast cancer
This study identifies four potential TNBC biomarkers for assessing TDAS abundance, providing novel insights and strategies for personalized TNBC treatment.
Authors
- Yao Tian (ORCID: https://orcid.org/0000-0003-4680-6889)
- Su Liu (ORCID: https://orcid.org/0000-0001-5177-5218)
- Guixin Wang (ORCID: https://orcid.org/0000-0002-4850-9207)
- Yingxi Li (ORCID: https://orcid.org/0000-0002-3848-1992)
- Shuo Wang (ORCID: https://orcid.org/0000-0002-7443-7999)
- Zhigang Zhao (ORCID: https://orcid.org/0000-0002-9327-9893)
- Junming Cao (ORCID: https://orcid.org/0009-0004-7581-2959)
Institutions
- Ningbo University (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Ningbo College of Health Sciences (CN)
- Ningbo University Affiliated Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fonc.2025.1705923
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00