The inflammatory architecture reflects the effects of pharmacological and genetic interventions on resolution of TLR2-mediated inflammation
Combined with previously published results in the same inflammation model, we find that a strong decrease or increase of the PI region negatively affects resolution of inflammation, whereas a moderate decrease of 30-50% is associated with in part strongly enhanced resolution of TLR2-mediated inflammation.
Authors
- Anja Kolbinger (ORCID: https://orcid.org/0000-0003-3120-7277)
- Sandra Pierre
- C Kramer
- Andreas Weigert (ORCID: https://orcid.org/0000-0002-7529-1952)
- Klaus Scholich (ORCID: https://orcid.org/0000-0003-3744-0854)
- Blerina Aliraj (ORCID: https://orcid.org/0009-0003-1553-7687)
- N. Zander
Institutions
- Goethe University Frankfurt (DE)
- University of Mannheim (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1633348
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft