Sulfotransferase SULT2B1 contributes to the epithelial–immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis
These findings suggest that increased SULT2B1 levels in the skin under psoriatic conditions may be involved in a negative feedback mechanism that helps to limit excessive skin inflammation, thereby potentially contributing to the maintenance of epithelial-immune microenvironment homeostasis. Overall, our results raise the possibility that SULT2B1 plays an important role in cutaneous inflammation and could serve as a useful indicator or potential target in psoriasis.
Authors
- Takeshi Nakahara
- Keisuke Matsubara (ORCID: https://orcid.org/0000-0002-0478-9753)
- Rae Maeda
- Masatomo Takahashi (ORCID: https://orcid.org/0000-0002-2493-2684)
- Yoshinori Fukui (ORCID: https://orcid.org/0000-0003-2335-8745)
- Daiji Sakata
- Sayaka Akiyoshi (ORCID: https://orcid.org/0000-0003-3798-5539)
- Takehito Uruno (ORCID: https://orcid.org/0000-0002-2812-9645)
- Kazufumi Kunimura (ORCID: https://orcid.org/0000-0002-3445-804X)
- Kenji Morino (ORCID: https://orcid.org/0000-0002-2235-9757)
- Yuki Sugiura (ORCID: https://orcid.org/0000-0002-6983-8958)
- Kazuhiko Yamamura (ORCID: https://orcid.org/0000-0001-9216-945X)
- Takeshi Bamba (ORCID: https://orcid.org/0000-0002-7442-2738)
- Yoshihiro Izumi (ORCID: https://orcid.org/0000-0003-4608-4652)
- Keisuke Nakata (ORCID: https://orcid.org/0000-0003-3767-1089)
- Satoshi Yotsumoto
Institutions
- Kagoshima University (JP)
- Kyushu University (JP)
- Kyoto University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1632426
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology